Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection"

Francis, SC; Hou, Y; Baisley, K; Van de wijgert, J; Watson-Jones, D; Ao, TT; Herrera, C; Maganja, K; Andreasen, A; Coulton, GR; Hayes, RJ and Shattock, RJ (2015). Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.104.
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An anonymised dataset containing details of a sub-study of 100 HIV-negative women in 2009. This sub-study was part of a microbicide feasibility study in North-West Tanzania that was carried out between 2008-2010. It contains information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination

Keywords

Cytokines; Chemokines; HIV; Microbicides; Vaccines; Sub-Saharan

Item Type Dataset
Resource Type
Resource Type
Resource Description
Dataset
UNSPECIFIED
Description of data capture This study was nested within a 12 month microbicide feasibility study of 970 HIV-negative women aged 18–44 years working in bars, hotels, and other food and recreational facilities in the three towns of Geita, Shinyanga and Kahama in northwestern Tanzania from 2008-2010. Participants enrolled in the sub-study were followed up three times a week for 4 weeks (12 visits total). At enrolment, interviews were carried out to obtain information about sexual behaviour, vaginal practices, current contraception, and STI symptoms. On the first and last visit (visits 1 & 12), a clinical and colposcopic examination were performed; cervical and vaginal swabs were collected to test for vaginal pH and reproductive tract infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and yeast); and a CVL was obtained for the detection of Herpes simplex virus, types 1 and 2 (HSV), prostate-specific antigen (PSA) to measure seminal plasma exposure in the last 48 hours, soluble immune proteins, haemoglobin and white blood cells (WBCs). During visits 2 to 11, a shortened interview was conducted to obtain updated sexual behaviours and intravaginal practices. A brief clinical examination was performed to obtain vaginal swabs for testing vaginal pH, bacterial vaginosis and yeast, and a CVL for the detection of HSV, PSA, soluble immune proteins, haemoglobin and WBCs. Urine was collected at every visit to test for pregnancy and menstrual cycle phase. If a woman was menstruating, no genital samples were obtained on that visit. No blood samples were collected; however laboratory data from the main cohort on HSV antibody status, HIV status and syphilis results were available for the statistical analysis and methods have been reported in a previous study. Colposcopy was carried out by trained clinicians according to the CONRAD/WHO revised manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products
Capture method Interview: Face-to-face, Physical measurements and tests
Collection Period
From
To
2008
2010
Date 24 November 2015
Geographical area covered (offline during plugin upgrade)
North Latitude
East Longitude
South Latitude
West Longitude
-2.8534
32.276
-2.91144
32.2067
-3.23592
34.3256
-3.52963
33.9881
-3.50223
32.8878
-4.05865
32.3103
Language(s) of written materials English
Creator(s) Francis, SC; Hou, Y; Baisley, K; Van de wijgert, J; Watson-Jones, D; Ao, TT; Herrera, C; Maganja, K; Andreasen, A; Coulton, GR; Hayes, RJ and Shattock, RJ
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023)
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions London School of Hygiene & Tropical Medicine; St George's, University of London; University of Liverpool; Imperial College London; National Institute for Medical Research
Funders
Project
Funder
Grant Number
Funder URI
Women’s Health Project: A HIV prevention trial feasibility study
European and Developing Countries Clinical Trials Partnership
UNSPECIFIED
UNSPECIFIED
UNSPECIFIED
Medical Research Council
UNSPECIFIED
UNSPECIFIED
UNSPECIFIED
International Partnership For Microbicides
UNSPECIFIED
UNSPECIFIED
UNSPECIFIED
Department for International Development
UNSPECIFIED
UNSPECIFIED
Date Deposited 09 May 2016 11:11
Last Modified 28 Sep 2018 21:17
Publisher London School of Hygiene & Tropical Medicine

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Description of variables contained within the dataset
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Data dictionary in MS Excel format, as produced by data creator
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