Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data

Karat, AS; Omar, T; von Gottberg, A; Tlali, M; Chihota, VN; Churchyard, GJ; Fielding, KL; Johnson, S; Martinson, NA; McCarthy, K; Wolter, N; Wong, EB; Charalambous, S and Grant, AD (2016). Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data. [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.122.
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Early mortality among HIV-positive adults starting antiretroviral therapy (ART) remains high in resource-limited settings, with tuberculosis (TB) the leading cause of death. However, current methods to estimate TB-related deaths are inadequate and most autopsy studies do not adequately represent those attending primary health clinics (PHCs). The TB Fast Track study aimed to determine the autopsy prevalence of TB and other infections in adults enrolled at South African PHCs in the context of a pragmatic trial of empiric TB treatment. This dataset contains basic demographic information and lab investigation results of 34 HIV-positive individuals who died after study enrolment. This includes MGIT culture and Xpert MTB/RIF; aerobic and fungal cultures; and histological findings

Keywords

Tuberculosis; HIV; Autopsy; Mortality; Disease prevalence; Minimally invasive autopsy; Cause of death; Opportunistic infections; Infectious Diseases; HIV diagnosis and management; Tuberculosis diagnosis and management; tuberculosis treatment; Cryptococcal meningitis; Pneumonia; Bacterial and viral diseases

Item Type Dataset
Resource Type
Resource Type
Resource Description
Dataset
UNSPECIFIED
Description of data capture Adults with CD4 150 cells/L, not on ART or TB treatment, were enrolled to TB Fast Track and followed up for at least six months. Minimally-invasive autopsy (MIA) was conducted as soon as possible after death. Lungs, liver, and spleen were biopsied; blood, CSF, and urine aspirated; and bronchoalveolar lavage fluid obtained. Samples underwent mycobacterial, bacterial, and fungal culture; molecular testing (including Xpert MTB/RIF); and histological examination.
Capture method Other
Collection Period
From
To
10 October 2013
3 June 2015
Date 6 May 2016
Geographical area covered (offline during plugin upgrade)
North Latitude
East Longitude
South Latitude
West Longitude
-23.7159
30.7727
-26.3042
27.2791
Language(s) of written materials English
Creator(s) Karat, AS; Omar, T; von Gottberg, A; Tlali, M; Chihota, VN; Churchyard, GJ; Fielding, KL; Johnson, S; Martinson, NA; McCarthy, K; Wolter, N; Wong, EB; Charalambous, S and Grant, AD
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023)
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre TB Centre
Participating Institutions London School of Hygiene & Tropical Medicine; The Aurum Institute, Johannesburg, South Africa; Foundation for Professional Development, Pretoria, South Africa; The University of the Witwatersrand, Johannesburg, South Africa; National Health Laboratory Services, South Africa; Perinatal HIV Research Unit, Soweto, Johannesburg, South Africa; Johns Hopkins Center for TB Research
Funders
Project
Funder
Grant Number
Funder URI
UNSPECIFIED
Bill & Melinda Gates Foundation
OPP1083118
UNSPECIFIED
Date Deposited 21 Oct 2016 13:53
Last Modified 28 Sep 2018 21:18
Publisher London School of Hygiene & Tropical Medicine

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Data / Code

MIADataSummary_CSV.csv
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Minimally-invasive Autopsy (MIA) data summary: CSV format
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MIADataSummary_Stata14.dta
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Minimally-invasive Autopsy (MIA) data summary: STATA format
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MIADataSummary_Codebook.pdf
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MIA Data Summary Codebook
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UserGuide.pdf
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User guide for Minimally-invasive Autopsy (MIA) data collection
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